The Six Great Shifts

Many languages have an equivalent to the expression “Seeing the forest for the trees”, meaning the ability to discern the big picture from little details. That ability is important in life but especially true for leaders of life sciences sector. Every day we are bombarded with news of innovative technology, tighter regulation and new approaches […]

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Validation Projects in China

Between 1997 and 2000 Pharmadule built a number of pharmaceutical manufacturing facilities in China for both domestic manufacturers and multi-national pharmaceutical companies, including Eli Lilly and AstraZeneca. The multi-national companies required GMP compliance and validation services comparable to the level that exist today. The facilities delivered for Chinese manufacturers would comply with international GMP requirements; […]

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Prophylactic and Therapeutic Vaccines

The ideal goal of cancer vaccine is to elicit potent anti-tumour immune responses without any contributing side-effects. The major aim is to stimulate both innate and adaptive immunity that can recognise and subsequently eliminate the tumours mass. Cancer immunotherapy continues to be a field of intense research, especially the induction of active immunity. The existence […]

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Biosimilar Medicines

Many of the blockbuster biological products that currently dominate the markets are coming to the end of their patent protection. The opportunity to provide more affordable “generic” versions is now attracting the interest of both generic and research-based pharmaceutical companies. The development of “generic” biological medicines referred to as “biosimilars” in Europe and increasingly in […]

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Unconventional Micro and Nanofabrication

Organismic assays are better and more predictive for testing putative therapeutics than molecular assays, but it is difficult and expensive to work with animals, and the relevance of these assays’ results in humans is often low. Human cell-based assays-which are less complicated than many organismic assays-are an attractive option for drug screening because cells are […]

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Enabling the Delivery of Poorly Soluble Drugs via Drug-Polymer Solid Dispersions

The advent of modern drug discovery techniques such as quantitative structure-activity relationships, combinatorial and high-throughput chemistry has contributed to this quest. The Lipinski Rule of 5 and variants thereof, acknowledge that potential drug molecules tend to be more lipophilic with logP values up to 5 and sometimes higher. Water solubility-enhancing formulation strategies have therefore become […]

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